Real-World Evidence Resources at the University of Pittsburgh
With the University of Pittsburgh serving as the lead site for the PaTH Clinical Research Network, Pitt’s Trilogue™ Center for Real-World Evidence is uniquely and strategically poised to facilitate access to PaTH and PCORnet’s vast networks of data and research collaborators. We offer step-by-step guidance and support to advance patient-centered research, implementation, and dissemination, whether funded through federal grants or industry sponsorship. Additionally, our alliance management team creates opportunities to connect with industry partners to pursue research of the highest possible impact for our patients.
Although the PaTH and other PCORnet research networks are our specialty for multi-site studies, Trilogue™ also encourages real-world research using the following resources for Pitt and UPMC researchers:
Data Warehousing and Informatics Resources
- Health Record Research Request (R3)
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A service and process of provisioning UPMC clinical data and of authorizing additional UPMC data sources for research provided by the Department of Biomedical Informatics (DBMI).
- Optum EHR Data
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Optum data is nationally representative, readily available, and includes granular data on patients and treatments. Data access is centralized and with secure virtual audited access through Pitt’s Health Sciences Research Database Center (HSRDC). For inquiries about using Optum data, please contact Stefanie Junker at sjunker@pitt.edu. **Jan 2023 update: Access to Optum is temporary unavailable through Pitt as upgrades are being implemented.**
Collaborative Programs Using Clinical Data
- All of Us Pennsylvania
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The University of Pittsburgh is one of the healthcare provider organizations for the national All of Us research program, a historic effort to gather data from 1 million people living in the United States.
- Consortium for Clinical Characterization of COVID-19 by EHR (4CE)
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4CE is an international consortium for electronic health record (EHR) data-driven studies of the COVID-19 pandemic. The goal of this effort is to inform doctors, epidemiologists and the public about COVID-19 patients with data acquired through the health care process.
- Genetic Information Commons
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The Genomic Information Commons (GIC) is a federated network that is developing two portals for researchers: (A) Prep-to- research portal. Investigators can execute genotype, phenotype, or combined genotype/phenotype queries, and receive aggregate results in real time; and (B) Study portal. With proper approvals, patient-level data are readily transferred to a cloud- hosted environment.
- PaTH Clinical Research Network
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PaTH is a Patient Centered Outcomes Research Institute (PCORI) Clinical Data Research Network focused on building a Learning Health System (LHS) for the Mid-Atlantic region. The PaTH network spans 13 universities and academic medical centers across four states. The University of Pittsburgh is the lead site and data coordinating center.
PaTH utilizes patient empowered research to address the questions and concerns that matter most to our communities to facilitate better health decisions. PaTH facilitates research by providing oversight, study design consultation, recruitment support and data. The PaTH network keeps up-to-date with informatics and security best practices in querying and sharing data from the PCORnet common data model (CDM).